Buy AICAR 50mg Online 99% Pure

Beyond metabolic health, AICAR has potential neuroprotective properties, with studies suggesting its role in supporting cognitive function and protecting against neurodegenerative diseases. It is also being explored for its anti-inflammatory effects and its ability to promote healthy cardiovascular function. AICAr-induced apoptosis and concurrent activation of AMPK were described in childhood acute lymphoblastic leukemia (ALL) cell lines 110, as well as in B cells isolated from patients with mantle cell lymphoma and steroids splenic marginal zone lymphoma 7. In chronic myelogenous leukemia (CML) cell lines 12 and primary samples 111, AICAr had antiproliferative effects, but AMPK knock-down by shRNA failed to prevent the effect of AICAr, indicating an AMPK-independent mechanism 12. Despite a very good response in one out of four patients, the trial was stopped because the highest dose of AICAr caused serious renal side effects in patients with severe comorbidities 10.

AICAR or 5-Aminoimidazole-4-carboxamide ribonucleotide, is a synthetic adenosine monophosphate analog. It was developed to stimulate the AMP-dependent protein kinase (AMPK) activity.12 It is currently being investigated as a protective agent against ischemic damage in the cardiac myocytes during cardiac injury. The AMP-activated protein kinase is an enzyme and a protein that may play a regulatory role in several metabolic pathways. Its expression has been observed in several tissues, including the skeletal muscles, liver, and brain. In all these tissues, it is considered to exert a potential net effect on lipogenesis and may inhibit cholesterol synthesis and ketogenesis. It may also modulate insulin secretion and skeletal muscle fatty acid oxidation with glucose uptake.

Are the prices for medications cheaper at online pharmacies than at physical pharmacies?

In many countries, AICAR is not approved for clinical use or over-the-counter sale as it is primarily used for research purposes. However, it may be available for purchase from research chemical suppliers for laboratory or scientific research purposes. The information has been gathered from numerous studies and analyses conducted over the years and is not intended for diagnosing, treating, or preventing any diseases. If you decide to purchase Aicar online, it is recommended to choose a verified and reliable supplier like Pen Peptide. However, it is always a good idea to conduct your own research and consult a specialist before using any supplements or medications. At Lawless Labs USA, we are committed to providing products of unparalleled quality and purity.

  • Adenosine is a potent vasodilator that plays a key role in reducing ischemia/reperfusion injury, but the applications for systemic adenosine are limited owing to peripheral hemodynamic actions 13.
  • The most widely used synthetic method for AICAR is by establishing a synthesis pathway starting from basic sugar molecules.
  • Even with more complex models of AMPK downregulation and knockout being introduced, AICAr remained a regular starting point for many studies focusing on AMPK biology.
  • AICAR has not achieved medical approval for humans from major regulatory bodies (FDA, EMA) as of 2024.
  • One meta-analysis aimed to investigate the potential of AICAR on cardiovascular tissues.(2) The data was collected from 5 randomized, placebo-controlled, double-blind clinical studies.

AICAr, AMPK, Proliferation and Cell Cycle

AICAR (5-aminoimidazole-4-carboxamide ribonucleoside), also known as acadesine, is a powerful AMP-kinase activator extensively used in animal research to explore energy homeostasis and metabolic regulation. This article delves into the diverse research applications of AICAR, emphasizing its role in insulin receptor regulation, muscle cell function modulation, anti-cancer properties, and cardioprotective effects during surgery. Due to AICAR’s impact on cellular metabolism and energy management, prospective therapeutic uses have attracted attention. It has been researched for its potential to increase muscle regeneration, enhance athletic performance, and treat metabolic illnesses like diabetes, obesity, and metabolic syndrome. Inflammation in adipocytes contributes to insulin resistance and poor blood glucose control. Research shows that AICAR has the ability to suppress inflammation in adipocytes that results in improved insulin sensitivity and glucose homeostasis.

This results in the effective reduction of blood glucose levels and insulin resistance 5. The study also noted that AICAR did not appear to affect p53 levels or phosphorylation, suggesting a p53-independent apoptosis mechanism in B-CLL cells. A comparison was made between normal B lymphocytes, T cells, and B-CLL cells’ sensitivity to AICAR-induced apoptosis. The findings indicated that normal B lymphocytes and B-CLL cells were similarly sensitive to AICAR-induced apoptosis, whereas T cells from B-CLL subjects appeared to show only minor sensitivity. Notably, AMPK phosphorylation did not seem to occur in T cells exposed to AICAR.